Clinical recommendations for defining platinum unsuitable head and neck cancer patient populations on chemoradiotherapy: A literature review
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AbstractToxicities resulting from platinum based chemotherapy in head and neck cancer is a cause for much concern. There is a lack of clinical criteria for defining these patient populations, which has posed serious problems associated with increased morbidity and consequently an adverse effect on patients' quality of life. In addition, there is a lack of consensus on clinical criteria for defining such patient populations, who may be unsuitable for concurrent chemoradiotherapy. A group of experts in the field of head and neck cancer from the Asia Pacific Region convened in August 2014 in Korea to discuss the development of a set of clinical criteria in order to fill the knowledge gap and provide a reference tool for head and neck oncologists. This paper reports the final output from this meeting and the accompanying literature review, with the aim of aiding clinical decision making with the help of some clinical criteria to identify platinum unsuitable patient populations in head and neck cancer management. Some alternative treatment options are also discussed in this paper.
All Author(s) ListAhn MJ, D'Cruz A, Vermorken JB, Chen JP, Chitapanarux I, Dang HQT, Guminski A, Kannarunimit D, Lin TY, Ng WT, Park KU, Chan ATC
Journal nameOral Oncology
Volume Number53
Pages10 - 16
LanguagesEnglish-United Kingdom
KeywordsCisplatin, Chemoradiotherapy, Criteria, Expert opinion, Head and neck cancer, Patients, Toxicity, Unsuitability
Web of Science Subject CategoriesOncology;Dentistry, Oral Surgery & Medicine;Oncology;Dentistry, Oral Surgery & Medicine

Last updated on 2020-24-11 at 01:50