Augmented Velocity Index: A New Doppler Index Associated with Arterial Stiffness
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摘要Augmented Velocity Index (Avi) is a new Doppler index developed to quantify velocity changes at the late systolic peak. We examined its reliability, association with arterial stiffness and cardiovascular risk factors. The Avi is calculated as (late systolic peak velocity − early systolic peak velocity)/(highest peak systolic velocity − end-diastolic velocity). Fifty volunteers (mean age ± standard deviation: 43.5 ± 14.2 y, men: 52%) without known medical illnesses or drug use were recruited. Carotid Doppler waveforms with measurements of Avi were recorded. Carotid pressure waveforms were obtained by applanation tonometry for measurement of the Augmentation Index (AI). Clinical measurements including body mass index (BMI) and blood pressure (BP) were assessed, and fasting blood was taken for measurement of glycemia and lipid profile. Another 15 volunteers (age range: 22–60 y, men: 33.3%) were recruited to study the reliability of Avi measurement. The results revealed that carotid Avi closely correlated with the index of arterial stiffness, AI (r = 0.76, p < 0.001) on Pearson correlation. On multiple linear regression analysis, Avi remained a significant independent determinant of AI after adjustments for clinical variables. The Avi had significant associations with cardiovascular risk factors (age, BMI, total cholesterol, low-density lipoprotein cholesterol, systolic and diastolic BP). The intra-class correlation coefficients for inter-observer and intra-observer reliability of Avi measurements were 0.93 (95% confidence interval [CI]: 0.8–0.98) and 0.97 (95% CI: 0.92–0.99) respectively. In conclusion, the Avi is a reproducible new Doppler index, independently associated with arterial stiffness in terms of the AI, which initially correlated with cardiovascular risk factors.
出版社接受日期09.06.2019
著者Kin Hung Liu, Winnie Chu, Alice Pik Shan Kong, Lai Yuk Yuen, Ling Chen, Ming Chung Lee, Rubee Pui Man Lau, Wing Hung Tam, Juliana Chung Ngor Chan, Anil Ahujja
期刊名稱Ultrasound in Medicine and Biology
出版年份2019
月份10
卷號45
期次10
出版社Elsevier
頁次2747 - 2757
國際標準期刊號0301-5629
語言英式英語

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