Augmented Velocity Index - A New Doppler Index Associated with Arterial Stiffness
Publication in refereed journal


摘要Augmented Velocity Index (Avi) is a new Doppler index developed to quantify velocity changes at late systolic peak. We examined its reliability, association with arterial stiffness and cardiovascular risk factors. Avi is defined as (late systolic peak velocity – early systolic peak velocity) / (highest peak systolic velocity - end-diastolic velocity). Fifty volunteers (mean age+SD: 43.5+14.2years, men: 52%) without known medical illnesses or drug use were recruited. Carotid Doppler waveforms with measurements of Avi were recorded. Carotid pressure waveforms were obtained by applanation tonometry for measurement of Augmentation Index (AI). Clinical measurements including body mass index (BMI) and blood pressure (BP) were assessed, and fasting blood was taken for measurement of glycaemia and lipid profile. Another 15 volunteers (Age range: 22-60 years, men: 33.3%) were recruited for the reliability study of Avi measurement. The result showed that carotid Avi was closely correlated with the index of arterial stiffness, AI (r=0.76, p<0.001) on Pearson correlation. On multiple linear regression analysis, Avi remained a significant independent determinant of AI after adjustments for clinical variables. The Avi had significant associations with cardiovascular risk factors (age, BMI, total cholesterol, LDL-cholesterol, systolic and diastolic BP). The intraclass correlation coefficients for inter-observer and intraobserver reliability of Avi measurements were 0.93 (95% CI: 0.8 – 0.98) and 0.97 (95% CI: 0.92 – 0.99) respectively. As a conclusion, Avi is a reproducible new Doppler index, which is independently associated with arterial stiffness in terms of AI, and has initial correlation with cardiovascular risk factors.
著者Kin Hung Liu, Winnie Chu, Alice Pik Shan Kong, Lai Yuk Yuen, Ling Chen, Ming Chung Lee, Rubee Pui Man Lau, Wing Hung Tam, Juliana Chung Ngor Chan, Anil Ahujja
期刊名稱Ultrasound in Medicine and Biology
頁次2747 - 2757

上次更新時間 2020-03-07 於 03:22