Status of inflammation in relation to health related quality of life in hepatocellular carcinoma patients
Publication in refereed journal

替代計量分析
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其它資訊
摘要Purpose
Both Inflammation and health-related quality of life (HRQoL) are independent prognosticators in HCC patients. We hypothesized that inflammation can cause impairment in HRQoL and investigated the correlation between inflammatory status and HRQoL in HCC patients.

Methods
Clinical, laboratory and HRQoL (using EORTC QLQ-C30, QLQ-HCC18, C30 and HCC18 index-scores) data were prospectively collected from HCC patients at diagnosis. Correlation analyses were performed between HRQoL and inflammation-based markers including C-reactive protein (CRP), CRP/albumin ratio (CRP/alb), Glasgow Prognostic Score (GPS), Inflammation-Based Index (IBI) and Prognostic Index (PI).

Results
Among 445 HCC patients, higher inflammatory states were significantly correlated with worse HRQoL. For CRP and CRP/alb ratio, the HRQoL factors with higher correlations included C30 and HCC18 index-scores, certain QLQ-C30 domains and items (‘physical functioning’, ‘role functioning’, ‘fatigue’, ‘pain’, ‘appetite loss’) and QLQ-HCC18 items (‘fatigue’, ‘body image’, ‘nutrition’ and ‘abdominal swelling’), where the Pearson’s correlation coefficients were up to 0.416. Multivariate analyses indicated that worse HRQoL factors were significantly correlated with worse scores in GPS, IBI and PI.

Conclusion
In HCC patients, inflammatory status correlates with HRQoL at presentation. In particular, relatively stronger correlations with CRP-based markers have been observed in HRQoL scales that assess constitutional symptoms (QLQ-C30 ‘physical functioning’, ‘role functioning’, ‘fatigue’, ‘appetite loss’ and QLQ-HCC18 ‘fatigue’ and ‘nutrition’) and tumor burden (QLQ-C30 ‘pain’ and QLQ-HCC18 ‘abdominal swelling’ and ‘body image’). Future studies are warranted to evaluate whether intervention that reduces inflammation could improve HRQoL in HCC patients.
出版社接受日期23.04.2019
著者Leung Li, Stephen L. Chan, Frankie Mo, Edwin P. Hui, Jane Koh, Allen KC Chan, Nelson LS Tang, Cheuk M. Chu, Joyce Hui, Kit F. Lee, Simon Yu, Winnie Yeo
期刊名稱Quality of Life Research
出版年份2019
月份9
卷號28
期次9
出版社Springer International Publishing
頁次2597 - 2607
國際標準期刊號0962-9343
電子國際標準期刊號1573-2649
語言英式英語
關鍵詞EORTC QLQ-C30, QLQ-HCC18, Index score, Liver cancer, C-reactive protein (CRP)

上次更新時間 2020-07-08 於 02:14