Clinical Ascertainment of Health Outcomes in Asian Survivors of Childhood Cancer: A Systematic Review
Publication in refereed journal

替代計量分析
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其它資訊
摘要Purpose
Survivorship in children with cancer comes at a cost of developing chronic treatment-related complications. Yet, it is still an under-researched area in Asia, which shares the largest proportion of the global childhood cancer burden given its vast population. This systematic review summarizes existing literature on clinically ascertained health outcomes in Asian survivors of childhood cancer.

Methods
A search was conducted on Ovid Medline and EMBASE for studies that focused on survivors of childhood cancer from countries in East and Southeast Asia; adopted post-treatment clinical ascertainment of organ-specific toxicities or/and secondary malignancy. Studies were excluded if health outcomes were assessed during the acute treatment.

Results
Fifty-nine studies, enrolling a total of 13,442 subjects, were conducted on survivors of leukemia (34%), CNS tumor (14%), and cohorts of survivors with heterogeneous cancer diagnoses (52%). The studies used different medical evaluation methods to assess cardiovascular (15%), metabolic and infertility (32%), and neurological/neurocognitive (20%) outcomes in survivors. The collective findings suggest potential differences in the prevalence of certain late effects (e.g., secondary malignancy and obesity) among Asian and non-Asian populations, which may reflect differences in treatment regimens, practice, genetic variations, or/and socioeconomic disparity.

Conclusions
We recommend developing collaborative initiatives to build a regional repository of systematically assessed health outcomes and biospecimens to investigate treatment, social-environmental and genetic predictors, and interventions for late effects in this population.

Implications for Cancer Survivors
The existing types of chronic health problems identified in this review suggest the need for active screening, better access to survivorship care, and promotion of protective health behavior in Asia.
出版社接受日期05.04.2019
著者Long Hin Jonathan Poon, Chun-Pong Yu, Liwen Peng, Celeste Lom-Ying Ewig, Hui Zhang, Chi-Kong Li, Yin Ting Cheung
期刊名稱Journal of Cancer Survivorship
出版年份2019
月份4
日期5
卷號13
期次3
出版社Springer (part of Springer Nature): Springer Open Choice Hybrid Journals
頁次374 - 396
國際標準期刊號1932-2259
語言美式英語
關鍵詞Childhood cancer, Late effects, Survivorship, Risk-based, Asian, Organ toxicity

上次更新時間 2020-12-08 於 03:24