Genetic Susceptibility of Hong Kong Ethnic Chinese to Severe Influenza and RSV Infections
Refereed conference paper presented and published in conference proceedings


摘要Introduction and Project Objectives
Influenza virus and respiratory syncytial virus (RSV) are major causes of severe respiratory infections worldwide. Accumulating data have suggested that genetic variation in host immunity related genes may play an important role in determining susceptibility to severe influenza or RSV diseases. The objective of this study was to investigate relationship of host genetic susceptibility to severe influenza and RSV infections among Hong Kong ethnic Chinese.

Methods / Implementation
This is a two-year prospective study and laboratory investigation. Adults (aged ≥18 years) hospitalized for influenza A or RSV infections in two acute-care, general public hospitals in Hong Kong were recruited. Single nucleotide polymorphisms (SNPs) of 4 genes related to innate immunity were determined by Sanger sequencing on host DNA isolated from respiratory samples: IFITM3 (rs12252), CD55 (rs2564978), TLR3 (rs5743313), and TLR4 (rs4986790 and rs4986791). Univariate and multivariate analyses were performed to study potential correlation of SNPs with clinical characteristics.

Results / Outcome
A total of 563 in-patients laboratory-confirmed with either influenza A virus or RSV infections between December 2014 and February 2017 were studied. Fatal cases (<3%) and risky SNP genotypes were less frequent than in our earlier study. In influenza A, there was a tendency of enrichment of IFITM3 genotype CC among those who developed pneumonia. Extensive effort was made to analyze potential correction of SNP genotype with an array of clinical parameters, including duration of hospitalization, requirement for oxygen or mechanical ventilation, ICU admission, and fatal outcome. However, no significant findings were observed.

We found no association of SNPs in IFITM3, CD55, and TLR3 with severe influenza A and RSV infections during mild seasons in ethnic Hong Kong Chinese. Host genetic factors may have strongest effect during initial phase of new virus emergence in a relatively immune naïve population. This should be considered in designing study to investigate genetic host factors with influenza severity.
著者Chan Martin Chi Wai, Lee Nelson, Ma Ronald Ching Wan, Graham Colin A, Chan Paul Kay Sheung
會議名稱Health Research Symposium 2019 - Genomics and Big Data in Health and Disease
會議地點Hong Kong
頁次76 - 77
關鍵詞influenza, host genetics, IFITM3, CD55, TLR3, TLR4

上次更新時間 2019-17-06 於 12:56