The Role of platelet-T cell interactions in pathogenesis of Multiple Sclerosis (MS) and Neuromyelitis Optica (NMO)
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AbstractIntroduction and Project Objectives:
Platelets are known to participate in vascular pathologies; however, their role in neuroinflammatory diseases, such as multiple sclerosis (MS), is unknown. Autoimmune CD4 T cells have been the main focus of studies of MS, although the factors that regulate T-cell differentiation toward pathogenic T helper-1/T helper-17 phenotypes are not completely understood. The main objective of the study was to understand the role of platelets in modulation of functions of pathogenic CD4 T cells in MS.
We investigated the role of platelets in the modulation of CD4 T-cell functions in patients with MS and in mice with experimental autoimmune encephalitis (EAE), an animal model for MS.
We found that early in MS and experimental autoimmune encephalitis, platelets degranulated and produced soluble factors serotonin (5-hydroxytryptamine), platelet factor 4, and platelet-activating factor, which specifically stimulated differentiation of T cells toward pathogenic T helper-1, T helper-17, and interferon-γ/interleukin-17-producing CD4 T cells. At the later stages of MS and experimental autoimmune encephalitis, platelets became exhausted in their ability to produce proinflammatory factors and stimulate CD4 T cells but substantially increased their ability to form aggregates with CD4 T cells. Formation of platelet-CD4 T-cell aggregates involved the interaction of CD62P on activated platelets with adhesion molecule CD166 on activated CD4 T cells, contributing to downmodulation of CD4 T-cell activation, proliferation, and production of interferon-γ. Blocking of formation of platelet-CD4 T-cell aggregates during progression of experimental autoimmune encephalitis substantially enhanced proliferation of CD4 T cells in the central nervous system and the periphery leading to exacerbation of the disease.
Our study indicates differential roles for platelets in the regulation of functions of pathogenic CD4 T cells during initiation and progression of central nervous system autoimmune inflammation.
Acceptance Date11/06/2019
All Author(s) ListStarossom S, Veremeyko T, Dukhinova M, Yung AWY, Lau AY, Au C, Ponomarev ED
Name of ConferenceHealth Research Symposium 2019
Start Date of Conference12/06/2019
End Date of Conference12/06/2019
Place of ConferenceHong Kong Academy of Medicine Jockey Club Building
Country/Region of ConferenceHong Kong
LanguagesEnglish-United Kingdom
KeywordsPlatelets, Multiple Sclerosis, brain lipid rafts, EAE

Last updated on 2019-20-06 at 12:13