A Molecular Switch Regulating Cell Fate Choice between Muscle Progenitor Cells and Brown Adipocytes
Publication in refereed journal

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其它資訊
摘要During mouse embryo development, both muscle progenitor cells (MPCs) and brown adipocytes (BAs) are known to derive from the same Pax7(+)/ Myf5(+) progenitor cells. However, the underlying mechanisms for the cell fate control remain unclear. In Pax7-null MPCs from young mice, several BA-specific genes, including Prdm16 and Ucp1 and many other adipocyte-related genes, were upregulated with a concomitant reduction of Myod and Myf5, two muscle lineage-determining genes. This suggests a cell fate switch from MPC to BA. Consistently, freshly isolated Pax7-null but not wild-type MPCs formed lipid-droplet-containing UCP1(+) BA in culture. Mechanistically, MyoD and Myf5, both known transcription targets of Pax7 in MPC, potently repress Prdm16, a BA-specific lineage-determining gene, via the E2F4/p107/p130 transcription repressor complex. Importantly, inducible Pax7 ablation in developing mouse embryos promoted brown fat development. Thus, the MyoD/Myf5E2F4/p107/p130 axis functions in both the Pax7(+/)Myf5+ embryonic progenitor cells and postnatal myoblasts to repress the alternative BA fate.
著者An YT, Wang G, Diao YR, Long YY, Fu XR, Weng MX, Zhou L, Sun K, Cheung TH, Ip NY, Sun H, Wang HT, Wu ZG
期刊名稱Developmental Cell
出版年份2017
月份5
日期22
卷號41
期次4
出版社CELL PRESS
出版地CAMBRIDGE
頁次382 - 391
國際標準期刊號1534-5807
語言英式英語
Web of Science 學科類別Cell Biology;Developmental Biology;Cell Biology;Developmental Biology

上次更新時間 2020-07-07 於 01:14