YY1 regulates skeletal muscle regeneration through controlling metabolic reprogramming of satellite cells
Publication in refereed journal

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其它資訊
摘要Skeletal muscle satellite cells (SCs) are adult muscle stem cells responsible for muscle regeneration after acute or chronic injuries. The lineage progression of quiescent SC toward activation, proliferation, and differentiation during the regeneration is orchestrated by cascades of transcription factors (TFs). Here, we elucidate the function of TF Yin Yang1 (YY1) in muscle regeneration. Muscle-specific deletion of YY1 in embryonic muscle progenitors leads to severe deformity of diaphragm muscle formation, thus neonatal death. Inducible deletion of YY1 in SC almost completely blocks the acute damage-induced muscle repair and exacerbates the chronic injury-induced dystrophic phenotype. Examination of SC revealed that YY1 loss results in cell-autonomous defect in activation and proliferation. Mechanistic search revealed that YY1 binds and represses mitochondrial gene expression. Simultaneously, it also stabilizes Hif1α protein and activates Hif1α-mediated glycolytic genes to facilitate a metabolic reprogramming toward glycolysis which is needed for SC proliferation. Altogether, our findings have identified YY1 as a key regulator of SC metabolic reprogramming through its dual roles in modulating both mitochondrial and glycolytic pathways.
著者Fengyuan Chen, Jiajian Zhou, Yuying Li, Yu Zhao, Jie Yuan, Yang Cao, Lijun Wang, Zongkang Zhang, Baoting Zhang, Chi Chiu Wang, Tom H Cheung, Zhenguo Wu, Carmen Chak‐Lui Wong, Hao Sun, Huating Wang
期刊名稱EMBO Journal
出版年份2019
月份5
卷號38
期次10
文章號碼e99727
國際標準期刊號0261-4189
電子國際標準期刊號1460-2075
語言英式英語

上次更新時間 2020-21-09 於 01:40