How OSA Evolves From Childhood to Young Adulthood - Natural History From a 10-Year Follow-up Study
Publication in refereed journal

替代計量分析
.

其它資訊
摘要Background
Understanding the natural history of childhood OSA can help to determine disease prognosis and to guide risk stratification and management strategies.

Methods
To evaluate the natural history of childhood OSA and factors associated with spontaneous remission and persistent and incident OSA from childhood to late adolescence/early adulthood, a longitudinal analysis of a prospective community-based cohort was designed. Subjects from a cohort established for an OSA prevalence study were invited to participate in this 10-year follow-up study.

Results
Two hundred and forty-three participants (59% male) took part, and their mean age was 9.8 (SD, ± 1.8) and 20.2 (SD, ± 1.9) years at baseline and follow-up, respectively. The mean follow-up duration was 10.4 (SD, ± 1.1) years. Associations between baseline and follow-up log-transformed obstructive apnea-hypopnea index (OAHI) differed by age; a significant positive association was observed only among participants aged 10 years or older at baseline. Overall polysomnographic remission rate (with OAHI < 1 event/h at follow-up) of childhood OSA was 30%, and 69% had an OAHI < 5 events/h at follow-up. Complete remission of OSA was associated with female sex. Incidence of adolescent/adult OSA with an OAHI ≥ 5 events/h at follow-up was 22%. Male sex and higher baseline BMI z score were associated with incident OSA.

Conclusions
A proportion of children with OSA, particularly female children, had complete resolution during transition to late adolescence or early adulthood. Childhood and adolescent OSA are distinct entities, with the latter more likely to persist into adulthood. Obesity and male sex are consistent key risk factors for incident OSA.
出版社接受日期02.03.2019
著者Kate C. Chan, Chun T. Au, L.L. Hui, Siu-kwan Ng, Yun K. Wing, Albert M. Li
期刊名稱Chest
出版年份2019
月份7
卷號156
期次1
出版社Elsevier
頁次120 - 130
國際標準期刊號0012-3692
語言美式英語
關鍵詞children, longitudinal study, natural history, sleep apnea

上次更新時間 2020-04-08 於 04:43