Replication Study for the Association of GWAS-associated Loci With Adolescent Idiopathic Scoliosis Susceptibility and Curve Progression in a Chinese Population
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AbstractStudy Design. A genetic association (replication) study.

Objective. The aim of this study was to replicate and further evaluate the association among seven genome-wide association studies (GWAS)-identified single nucleotide polymorphisms (SNPs) in Chinese girls with adolescent idiopathic scoliosis (AIS) with disease onset, curve types, and progression.

Summary of Background Data. AIS is the most common pediatric spinal deformity with a strong genetic predisposition. Recent GWAS identified 10 new disease predisposition loci for AIS.

Methods. Three hundred nineteen female AIS patients with Cobb angle ≥ 10o and 201 healthy controls were studied for the association with disease onset. Seven GWAS-identified SNPs (rs11190870 in LBX1, rs12946942 in SOX9/KCNJ2, rs13398147 in PAX3/EPH4, rs241215 in AJAP1, rs3904778 in BNC2, rs6570507 in GPR126, and rs678741 in LBX1-AS1) were analyzed. In subgroup analysis, AIS patients were subdivided by curve types and disease progression to examine for genotype association.

Results. We replicated the association with disease onset in four common SNPs rs11190870, rs3904778, rs6570507, and rs678741. In addition, rs1190870 and rs678741 remained significantly associated in the right thoracic curves only subgroup. However, no significant difference was observed with both clinical curve progression or Cobb angle.

Conclusion. This study replicated the associations of four GWAS-associated SNPs with occurrence of AIS in our Chinese population. However, none of these SNPs was associated with curve severity and progression. The results suggest that curve progression may be determined by environmental (nongenetic) factor, but further study with a larger sample size is required to address this issue.

Level of Evidence: 4
Acceptance Date01/04/2019
All Author(s) ListMan GC, Tang NL, Chan TF, Lam TP, Li JW, Ng BK, Zhu Z, Qiu Y, Cheng JC
Journal nameSpine
Year2019
Month4
Volume Number44
Issue Number7
Pages464 - 471
ISSN0362-2436
eISSN1528-1159
LanguagesEnglish-United Kingdom

Last updated on 2020-26-03 at 02:41