Hypoxia Causes Transgenerational Impairment of Ovarian Development and Hatching Success in Fish
Publication in refereed journal

香港中文大學研究人員
替代計量分析
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其它資訊
摘要Hypoxia is a pressing environmental problem in both marine and freshwater ecosystems globally, and this problem will be further exacerbated by global warming in the coming decades. Recently, we reported that hypoxia can cause transgenerational impairment of sperm quality and quantity in fish (in F0, F1, and F2 generations) through DNA methylome modifications. Here, we provide evidence that female fish (Oryzias melastigma) exposed to hypoxia exhibit reproductive impairments (follicle atresia and retarded oocyte development), leading to a drastic reduction in hatching success in the F2 generation of the transgenerational group, although they have never been exposed to hypoxia. Further analyses show that the observed transgenerational impairments in ovarian functions are related to changes in the DNA methylation and expression pattern of two gene clusters that are closely associated with stress-induced cell cycle arrest and cell apoptosis. The observed epigenetic and transgenerational alterations suggest that hypoxia may pose to the sustainability of natural fish populations.
著者Lai KP, Wang SY, Li JW, Tong Y, Chan TF, Jin NN, Tse A, Zhang JW, Wan MT, Tam N, Au DWT, Lee BY, Lee JS, Wong AST, Kong RYC, Wu RSS
期刊名稱Environmental Science and Technology
出版年份2019
月份4
卷號53
期次7
出版社AMER CHEMICAL SOC
頁次3917 - 3928
國際標準期刊號0013-936X
電子國際標準期刊號1520-5851
語言英式英語
Web of Science 學科類別Engineering, Environmental;Environmental Sciences;Engineering;Environmental Sciences & Ecology

上次更新時間 2020-25-09 於 03:25