Hypoxia Causes Transgenerational Impairment of Ovarian Development and Hatching Success in Fish
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AbstractHypoxia is a pressing environmental problem in both marine and freshwater ecosystems globally, and this problem will be further exacerbated by global warming in the coming decades. Recently, we reported that hypoxia can cause transgenerational impairment of sperm quality and quantity in fish (in F0, F1, and F2 generations) through DNA methylome modifications. Here, we provide evidence that female fish (Oryzias melastigma) exposed to hypoxia exhibit reproductive impairments (follicle atresia and retarded oocyte development), leading to a drastic reduction in hatching success in the F2 generation of the transgenerational group, although they have never been exposed to hypoxia. Further analyses show that the observed transgenerational impairments in ovarian functions are related to changes in the DNA methylation and expression pattern of two gene clusters that are closely associated with stress-induced cell cycle arrest and cell apoptosis. The observed epigenetic and transgenerational alterations suggest that hypoxia may pose to the sustainability of natural fish populations.
All Author(s) ListLai KP, Wang SY, Li JW, Tong Y, Chan TF, Jin NN, Tse A, Zhang JW, Wan MT, Tam N, Au DWT, Lee BY, Lee JS, Wong AST, Kong RYC, Wu RSS
Journal nameEnvironmental Science and Technology
Year2019
Month4
Volume Number53
Issue Number7
PublisherAMER CHEMICAL SOC
Pages3917 - 3928
ISSN0013-936X
eISSN1520-5851
LanguagesEnglish-United Kingdom
Web of Science Subject CategoriesEngineering, Environmental;Environmental Sciences;Engineering;Environmental Sciences & Ecology

Last updated on 2020-11-07 at 03:17