Mechanotransduction and Cytoskeleton Remodeling Shaping YAP1 in Gastric Tumorigenesis
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AbstractThe essential role of Hippo signaling pathway in cancer development has been elucidated by recent studies. In the gastrointestinal tissues, deregulation of the Hippo pathway is one of the most important driving events for tumorigenesis. It is widely known that Yes-associated protein 1 (YAP1) and WW domain that contain transcription regulator 1 (TAZ), two transcriptional co-activators with a PDZ-binding motif, function as critical effectors negatively regulated by the Hippo pathway. Previous studies indicate the involvement of YAP1/TAZ in mechanotransduction by crosstalking with the extracellular matrix (ECM) and the F-actin cytoskeleton associated signaling network. In gastric cancer (GC), YAP1/TAZ functions as an oncogene and transcriptionally promotes tumor formation by cooperating with TEAD transcription factors. Apart from the classic role of Hippo-YAP1 cascade, in this review, we summarize the current investigations to highlight the prominent role of YAP1/TAZ as a mechanical sensor and responder under mechanical stress and address its potential prognostic and therapeutic value in GC.
All Author(s) ListZhang J, Zhou Y, Tang PMK, Cheng ASL, Yu J, To KF, Kang W
Journal nameInternational Journal of Molecular Sciences
Year2019
Month3
Volume Number20
Issue Number7
PublisherMDPI
Article number1576
ISSN1661-6596
LanguagesEnglish-United Kingdom
KeywordsHippo pathway, YAP1, mechanical strain, F-actin, gastric cancer

Last updated on 2020-11-07 at 03:18