Aspirin in coronary artery surgery: 1-year results of the Aspirin and Tranexamic Acid for Coronary Artery Surgery trial.
Publication in refereed journal


Times Cited
Altmetrics Information
.

Other information
AbstractBackground
Aspirin may reduce the risk of vascular graft thrombosis after cardiovascular surgery. We previously reported the 30-day results of a trial evaluating aspirin use before coronary artery surgery. Here we report the 1-year outcomes evaluating late thrombotic events and disability-free survival.

Methods
Using a factorial design, we randomly assigned patients undergoing coronary artery surgery to receive aspirin or placebo and tranexamic acid or placebo. The results of the aspirin comparison are reported here. The primary 1-year outcome was death or severe disability, the latter defined as living with a modified Katz activities of daily living score < 8. Secondary outcomes included a composite of myocardial infarction, stroke and death from any cause through to 1 year after surgery.

Results
Patients were randomly assigned to aspirin (1059 patients) or placebo (1068 patients). The rate of death or severe disability was 4.1% in the aspirin group and 3.5% in the placebo group (relative risk, 1.17; 95% confidence interval, 0.76-1.81; P = .48). There was no significant difference in the rates of myocardial infarction ( P = .11), stroke ( P = .086), or death ( P = .24), or a composite of these cardiovascular end points ( P = .68). With the exception of those with a low European System for Cardiac Operative Risk Evaluation score ( P = .03), there were no interaction effects on these outcomes with tranexamic acid (all tests of interaction P > .10).

Conclusions
In patients undergoing coronary artery surgery, preoperative aspirin did not reduce death or severe disability, or thrombotic events through to 1 year after surgery.
All Author(s) ListMyles PS, Smith JA, Kasza J, Silbert B, Jayarajah M, Painter T, Cooper DJ, Marasco S, McNeil J, Bussières JS, McGuinness S, Chan MTV, Wallace S, Forbes A; ATACAS investigators and the ANZCA Clinical Trials Network
Journal nameJournal of Thoracic and Cardiovascular Surgery
Year2019
Month2
Volume Number157
Issue Number2
PublisherElsevier
Pages633 - 640
ISSN0022-5223
LanguagesEnglish-United Kingdom

Last updated on 2020-21-10 at 02:30