Mitochondria Manipulation in Oocytes: A Mini-Review
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AbstractMitochondria are the most abundant cellular organelles in the mammalian oocyte. Growing evidence has shown they play a crucial role in oocyte development and reproduction. In the field of reproductive biology, the manipulation of mitochondria has received attention from scientists for decades. In this mini-review, we discuss the background and new findings of mitochondria manipulation methods, and possible approaches for mitochondria transfer. The use of donor ooplasm transfer to improve oocyte quality has obtained ten live births. However, donor mitochondria were identified in the offspring. This method aroused serious ethical consideration and finally was banned by government regulation. Microinjection of purified/concentrated mitochondria from patient’s own somatic cells became an alternative source for oocyte augmentation to avoid ethical concerns. Since somatic cell mitochondria possibly contain high mutations or deletions, the choice of using mitochondria should be selected carefully. Mitochondria in oogonial stem cells (OSCs) are considered to be of the highest quality since they are the origin of oocyte mitochondria. Autologous mitochondria transfer from the patient’s own OSCs has resulted in live births, but animal’s studies and randomized controlled studies are lacking in this field. Currently, microinjection is the dominant method for mitochondria replacement therapy. There is potential for such invasive manipulation to be replaced since the discoveries of new inter-cell communication via gametic synapses and tunnelling nanotubes (TNT).
Acceptance Date11/12/2017
All Author(s) ListZhao Mingpeng, Li Tin Chiu, Chan Yiu Leung David
Journal nameCommunication, Culture and Critique
Volume Number1
Issue Number1
Pages1 - 5
LanguagesEnglish-United Kingdom
KeywordsMitochondria, Oocytes, DNA

Last updated on 2019-18-06 at 09:24