MicroRNA signature of air pollution exposure-induced congenital defects
Publication in refereed journal

替代計量分析
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其它資訊
摘要Air pollution exposure has been increasing extensively and there are evidence suggesting that exposure to air pollution during pregnancy can lead to congenital defects in the offspring. Recent findings suggested that microRNAs (miRNAs) might play important roles in the pathogenesis of developmental defects. However, the miRNAs profile pattern in the air pollution-exposed embryos remains unknown. RNA sequencing was performed to determine the differentially expressed miRNAs in the rat embryos (gestation day 9) with or without air pollution exposure. The potential functions and the associated mechanisms of these differentially expressed miRNAs were determined using Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway and Gene Ontology (GO) analyses. The regulatory networks of mRNA-miRNA interactions were also reconstructed. As compared with the control group, a total of 291 miRNAs were differentially expressed in the rat embryos from the air pollution-exposed group, in which 204 and 87 miRNAs were significantly downregulated and upregulated, respectively. These miRNAs were predicted to deregulate mitotic spindle organization, cellular respiration, glycolate metabolism, and proteasome. Extensive regulation of target genes by miR-346, miR-504, miR-214-3p and miR-1224 was also predicted. Our results suggested that miRNAs may play crucial roles in the pathogenesis of air pollution-induced congenital spinal defects through deregulating multiple biological processes.
出版社接受日期14.02.2019
著者Li Z, Ma J, Bi J, Guo H, Chan MTV, Wu WKK, Wu Z, Shen J
期刊名稱Journal of Cellular Physiology
出版年份2019
月份10
卷號234
期次10
出版社Wiley
頁次17896 - 17904
國際標準期刊號0021-9541
電子國際標準期刊號1097-4652
語言英式英語
關鍵詞air pollution, congenital defects, congenital scoliosis, microRNAs

上次更新時間 2021-10-01 於 02:04