Exhaled air dispersion during high-flow nasal cannula therapy versus CPAP via different masks
Publication in refereed journal

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摘要Background: High-flow nasal cannula (HFNC) is an emerging therapy for respiratory failure but the extent of exhaled air dispersion during treatment is unknown. We examined exhaled air dispersion during HFNC therapy versus continuous positive airway pressure (CPAP) on a human patient simulator (HPS) in an isolation room with 16 air changes.h(-1).

Methods: The HPS was programmed to represent different severity of lung injury. CPAP was delivered at 5-20 cm H2O via nasal pillows (Respironics Nuance Pro Gel or ResMed Swift FX) or an oronasal mask (ResMed Quattro Air). HFNC, humidified to 37 degrees C, was delivered at 10-60 L.min(-1) to the HPS. Exhaled airflow was marked with intrapulmonary smoke for visualisation and revealed by laser light-sheet. Normalised exhaled air concentration was estimated from the light scattered by the smoke particles. Significant exposure was defined when there was. 20% normalised smoke concentration.

Results: In the normal lung condition, mean +/- SD exhaled air dispersion, along the sagittal plane, increased from 186 +/- 34 to 264 +/- 27 mm and from 207 +/- 11 to 332 +/- 34 mm when CPAP was increased from 5 to 20 cmH2O via Respironics and ResMed nasal pillows, respectively. Leakage from the oronasal mask was negligible. Mean +/- SD exhaled air distances increased from 65 +/- 15 to 172 +/- 33 mm when HFNC was increased from 10 to 60 L.min(-1). Air leakage to 620 mm occurred laterally when HFNC and the interface tube became loose.

Conclusion: Exhaled air dispersion during HFNC and CPAP via different interfaces is limited provided there is good mask interface fitting.
出版社接受日期16.01.2019
著者David S. Hui, Benny K. Chow, Thomas Lo, Owen T.Y. Tsang, Fanny W. Ko, Susanna S. Ng, Tony Gin, Matthew T.V. Chan
期刊名稱European Respiratory Journal
出版年份2019
月份4
卷號53
期次4
出版地UK
文章號碼1802339
國際標準期刊號0903-1936
語言英式英語

上次更新時間 2020-18-09 於 03:08