Maternal glucose levels during pregnancy and childhood adiposity in the Hyperglycemia and Adverse Pregnancy Outcome Follow-up Study
Publication in refereed journal

香港中文大學研究人員
替代計量分析
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其它資訊
摘要Aims/hypothesis
Maternal type 2 diabetes during pregnancy and gestational diabetes are associated with childhood adiposity; however, associations of lower maternal glucose levels during pregnancy with childhood adiposity, independent of maternal BMI, remain less clear. The objective was to examine associations of maternal glucose levels during pregnancy with childhood adiposity in the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) cohort.
Methods
The HAPO Study was an observational epidemiological international multi-ethnic investigation that established strong associations of glucose levels during pregnancy with multiple adverse perinatal outcomes. The HAPO Follow-up Study (HAPO FUS) included 4832 children from ten HAPO centres whose mothers had a 75 g OGTT at ~28 weeks gestation 10–14 years earlier, with glucose values blinded to participants and clinical caregivers. The primary outcome was child adiposity, including: (1) being overweight/obese according to sex- and age-specific cut-offs based on the International Obesity Task Force (IOTF) criteria; (2) IOTF-defined obesity only; and (3) measurements >85th percentile for sum of skinfolds, waist circumference and per cent body fat. Primary predictors were maternal OGTT and HbA1c values during pregnancy.
Results
Fully adjusted models that included maternal BMI at pregnancy OGTT indicated positive associations between maternal glucose predictors and child adiposity outcomes. For one SD difference in pregnancy glucose and HbA1c measures, ORs for each child adiposity outcome were in the range of 1.05–1.16 for maternal fasting glucose, 1.11–1.19 for 1 h glucose, 1.09–1.21 for 2 h glucose and 1.12–1.21 for HbA1c. Associations were significant, except for associations of maternal fasting glucose with offspring being overweight/obese or having waist circumference >85th percentile. Linearity was confirmed in all adjusted models. Exploratory sex-specific analyses indicated generally consistent associations for boys and girls.
Conclusions/interpretation
Exposure to higher levels of glucose in utero is independently associated with childhood adiposity, including being overweight/obese, obesity, skinfold thickness, per cent body fat and waist circumference. Glucose levels less than those diagnostic of diabetes are associated with greater childhood adiposity; this may have implications for long-term metabolic health.
出版社接受日期12.12.2018
著者Lowe William L., Lowe Lynn P., Kuang Alan, Catalano Patrick M., Nodzenski Michael, Talbot Octavious, Tam Wing-Hung, Sacks David A., McCance David, Linder Barbara, Lebenthal Yael, Lawrence Jean M., Lashley Michele, Josefson Jami L., Hamilton Jill, Deerochanawong Chaicharn, Clayton Peter, Brickman Wendy J., Dyer Alan R., Scholtens Denise M., Metzger Boyd E., on behalf of the HAPO Follow-up Study Cooperative Research Group
期刊名稱Diabetologia
出版年份2019
月份4
卷號62
期次4
出版社Springer
頁次598 - 610
國際標準期刊號0012-186X
電子國際標準期刊號1432-0428
語言英式英語
關鍵詞Adiposity, Childhood obesity, Glucose, Pregnancy

上次更新時間 2020-07-08 於 02:07