How to Make the Best Use of Immunotherapy as First-Line Treatment for Advanced/Metastatic Non-Small-Cell Lung Cancer
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AbstractAntibodies that target programmed death 1 (PD-1) or its ligand (programmed death ligand 1 (PD-L1) have become a mainstay of first-line treatment of advanced/metastatic non-small-cell lung cancer (NSCLC) without targetable genetic alterations. In this review, we summarize results from recent clinical trials that have evaluated the anti-PD-1 antibodies pembrolizumab and nivolumab and the anti-PD-L1 antibodies atezolizumab and durvalumab as first-line treatment as monotherapy, in combination with chemotherapy, other immunotherapies, and anti-angiogenesis agents. We discuss factors that may influence treatment selection, including patient baseline clinical and demographic characteristics, tumor histology, and biomarkers such as PD-L1 expression and tumor mutation burden. While immunotherapy has become a central component of first-line treatment for most patients with advanced NSCLC, important questions remain about how treatment should be managed for individual patients
Acceptance Date26/03/2019
All Author(s) ListPeters S, Reck M, Smit EF, Mok T, Hellmann MD
Journal nameAnnals of Oncology
Year2019
Month6
Volume Number30
Issue Number6
PublisherOxford University Press
Pages884 - 896
ISSN0923-7534
LanguagesEnglish-United Kingdom
KeywordsNon-Small-Cell Lung Cancer

Last updated on 2020-06-07 at 02:07