Management of common adverse events related to first-line dacomitinib use in EGFR mutation-positive non-small-cell lung cancer: a pooled safety analysis
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AbstractAIM:
This pooled safety analysis was conducted to analyze incidence and management of key dacomitinib-associated adverse drug reactions (ADRs).

PATIENTS & METHODS:
Patients with EGFR mutation-positive advanced non-small-cell lung cancer who received first-line dacomitinib at the 45 mg/day recommended starting dose were included. ADRs were identified based on reasonable association with EGFR tyrosine kinase inhibitors.

RESULTS:
Overall, 251/255 patients (98%) experienced ADRs. The most common were diarrhea, rash, stomatitis, nail disorder and dry skin. Dose interruptions and dose reductions were reported in 47 and 52% of patients, respectively. Fewer Grade 3 key ADRs were observed following dose reductions.

CONCLUSION:
Dacomitinib was generally tolerable. Most reported ADRs were known to be associated with EGFR tyrosine kinase inhibitors and were managed with standard medical management and dose modifications.
All Author(s) ListZhou Q, Wu YL, Corral J, Nakagawa K, Garon EB, Sbar EI, Wang T, Sandin R, Noonan K, Gernhardt D, Mok TS
Journal nameFuture Oncology
Year2019
Month5
Volume Number15
Issue Number13
Place of PublicationEngland
Pages1481 - 1491
ISSN1479-6694
eISSN1744-8301
LanguagesEnglish-United Kingdom
Keywordsdacomitinib, non-small-cell lung cancer

Last updated on 2020-28-06 at 02:24