Tissue iron is negatively correlated with TERC or TERT mRNA expression: A heterochronic parabiosis study in mice
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摘要To test the hypothesis that iron accumulation in tissues with age is a key harmful factor for the development of aging, we established heterochronic parabiosis-pairings and investigated changes in serum iron, the expression of major iron transport proteins and iron contents, as well as telomerase reverse transcriptase (TERT), telomerase RNA component (TERC), and telomere length in the liver, kidney and heart of Y-O(O) (old pairing with young), Y-O(Y) (young pairing with old), O-O (pairings between two old) and Y-Y (pairings between two young) mice. We demonstrated that the reduced serum iron, increased iron and reduced expression of TERT and TERC in the tissues of aged mice are reversible by exposure to a younger mouse’s circulation. All of these measurements in young mice are reversible by exposure to an older mouse’s circulation. Correlation analysis showed that tissue iron is negatively correlated with TERT and TERC expression in the liver, kidney and heart of parabiotic mice. These findings provide new evidence for the key role of iron in aging and also imply the existence of rejuvenating factors in young serum with an anti-ageing role that act by reversing the impaired activity of iron metabolism in old mice.
著者Meng-Wan ZHANG, Peng ZHAO, Wing-Ho YUNG, Yuan SHENG, Ya KE, Zhong-Ming QIAN
期刊名稱Aging
出版年份2018
月份12
日期16
卷號10
期次12
頁次3834 - 3850
國際標準期刊號1945-4589
語言英式英語

上次更新時間 2020-21-10 於 02:27