Risk of intracerebral haemorrhage in Chinese patients with atrial fibrillation on warfarin with cerebral microbleeds: The IPAAC-Warfarin study
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AbstractBACKGROUND AND PURPOSE:
Cerebral microbleeds (CMBs), which predict future intracerebral haemorrhage (ICH), may guide anticoagulant decisions for atrial fibrillation (AF). We aimed to evaluate the risk of warfarin-associated ICH in Chinese patients with AF with CMBs.

METHODS:
In this prospective, observational, multicentre study, we recruited Chinese patients with AF who were on or intended to start anticoagulation with warfarin from six hospitals in Hong Kong. CMBs were evaluated with 3T MRI brain at baseline. Primary outcome was clinical ICH at 2-year follow-up. Secondary outcomes were ischaemic stroke, systemic embolism, mortality of all causes and modified Rankin Scale ≥3. Outcome events were compared between patients with and without CMBs.

RESULTS:
A total of 290 patients were recruited; 53 patients were excluded by predefined criteria. Among the 237 patients included in the final analysis, CMBs were observed in 84 (35.4%) patients, and 11 had ≥5 CMBs. The mean follow-up period was 22.4±10.3 months. Compared with patients without CMBs, patients with CMBs had numerically higher rate of ICH (3.6% vs 0.7%, p=0.129). The rate of ICH was lower than ischaemic stroke for patients with 0 to 4 CMBs, but higher for those with ≥5 CMBs. CMB count (C-index 0.82) was more sensitive than HAS-BLED (C-index 0.55) and CHA2DS2-VASc (C-index 0.63) scores in predicting ICH.

CONCLUSIONS:
In Chinese patients with AF on warfarin, presence of multiple CMBs may be associated with higher rate of ICH than ischaemic stroke. Larger studies through international collaboration are needed to determine the risk:benefit ratio of oral anticoagulants in patients with AF of different ethnic origins.
Acceptance Date29/10/2018
All Author(s) ListSoo Y, Abrigo JM, Leung KT, Tsang SF, Ip HL, Ma SH, Ma K, Fong WC, Li SH, Li R, Ng PW, Wong KK, Liu W, Lam BYK, Wong KSL, Mok V, Chu WCW, Leung TW, IPAAC study group
Journal nameJournal of Neurology, Neurosurgery and Psychiatry
Detailed descriptionEpub on 17.12.2018
Year2019
Month4
Volume Number90
Issue Number4
Pages428 - 435
ISSN0022-3050
eISSN1468-330X
LanguagesEnglish-United States
KeywordsCerebral Microbleeds, intracerebral haemorrhage, atrial fibrillation, warfarin

Last updated on 2020-28-05 at 02:16