Amide proton transfer MRI detects early changes in nasopharyngeal carcinoma: providing a potential imaging marker for treatment response
Publication in refereed journal

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摘要Purpose: To determine if treatment of nasopharyngeal carcinoma (NPC) induces early changes in amide proton transfer-weighted (APTw) magnetic resonance imaging (MRI), and to perform a preliminary evaluation of APTw imaging in response assessment.
Methods: Sixteen patients with NPC planned for treatment with radiotherapy and/or chemotherapy underwent APTw imaging of the primary tumour pre-treatment and 2-week intra-treatment. Difference in pre- and intra-treatment APT mean (APTmean) was compared using the Wilcoxon signed rank test. Differences in APTmean and percentage change (%Δ) in APTmean were compared between responders and non-responders based on the outcome at 6 months, using the Mann–Whitney U test.
Results: APTmean decreased in 9/16 (56.3%) and increased in 7/16 (43.7%) with no significant difference between the pre- and intra-treatment APT values for the whole group (p > 0.05). NPC showed response in 11/16 (68.8%) and non-response in 5/11 (31.2%). There were significant differences between the %Δ of responders and non-responders for APTmean (p = 0.01). Responders showed %Δ decrease in APTmean of − 23.12% while non-responders showed a %Δ increase in APTmean of + 102.28%.
Conclusion: APT value changes can be detected in early intra-treatment. Intra-treatment %Δ APTmean shows potential in predicting short-term outcome.
出版社接受日期28.11.2018
著者Qamar S, King AD, Ai QY, Law BKH, Chan JSM, Poon DMC, Tong M, Mo FKF, Chen W, Bhatia KS, Ahuja AT, Ma BBY, Yeung DK, Wang YX, Yuan J
期刊名稱European Archives of Oto-Rhino-Laryngology
出版年份2019
月份2
卷號276
期次2
出版社Springer
頁次505 - 512
國際標準期刊號0937-4477
電子國際標準期刊號1434-4726
語言美式英語
關鍵詞Amide proton transfer-weighted imaging, Chemical exchange saturation transfer, Magnetic resonance imaging, Nasopharyngeal carcinoma, Treatment response

上次更新時間 2020-06-07 於 01:58