Amide proton transfer MRI detects early changes in nasopharyngeal carcinoma: providing a potential imaging marker for treatment response
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AbstractPurpose: To determine if treatment of nasopharyngeal carcinoma (NPC) induces early changes in amide proton transfer-weighted (APTw) magnetic resonance imaging (MRI), and to perform a preliminary evaluation of APTw imaging in response assessment.
Methods: Sixteen patients with NPC planned for treatment with radiotherapy and/or chemotherapy underwent APTw imaging of the primary tumour pre-treatment and 2-week intra-treatment. Difference in pre- and intra-treatment APT mean (APTmean) was compared using the Wilcoxon signed rank test. Differences in APTmean and percentage change (%Δ) in APTmean were compared between responders and non-responders based on the outcome at 6 months, using the Mann–Whitney U test.
Results: APTmean decreased in 9/16 (56.3%) and increased in 7/16 (43.7%) with no significant difference between the pre- and intra-treatment APT values for the whole group (p > 0.05). NPC showed response in 11/16 (68.8%) and non-response in 5/11 (31.2%). There were significant differences between the %Δ of responders and non-responders for APTmean (p = 0.01). Responders showed %Δ decrease in APTmean of − 23.12% while non-responders showed a %Δ increase in APTmean of + 102.28%.
Conclusion: APT value changes can be detected in early intra-treatment. Intra-treatment %Δ APTmean shows potential in predicting short-term outcome.
Acceptance Date28/11/2018
All Author(s) ListQamar S, King AD, Ai QY, Law BKH, Chan JSM, Poon DMC, Tong M, Mo FKF, Chen W, Bhatia KS, Ahuja AT, Ma BBY, Yeung DK, Wang YX, Yuan J
Journal nameEuropean Archives of Oto-Rhino-Laryngology
Year2019
Month2
Volume Number276
Issue Number2
PublisherSpringer
Pages505 - 512
ISSN0937-4477
eISSN1434-4726
LanguagesEnglish-United States
KeywordsAmide proton transfer-weighted imaging, Chemical exchange saturation transfer, Magnetic resonance imaging, Nasopharyngeal carcinoma, Treatment response

Last updated on 2020-06-07 at 01:58