Observed changes in brown, white, hepatic and pancreatic fat after bariatric surgery: Evaluation with MRI
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摘要ObjectivesTo study the change in brown and white adipose tissue (BAT and WAT), as well as fat content in the liver and pancreas, in patients with morbid obesity before and after bariatric surgery.MethodsTwelve patients with morbid obesity (F=8, M=4, age: 45.4 years (38.4-51.2), BMI: 35.2 kg/m(2) (32.5-38.6)) underwent pre-op MRI at baseline and two post-op scans at 6-month and 12-month intervals after bariatric surgery. Co-registered water, fat, fat-fraction and T2* image series were acquired. Supraclavicular BAT and abdominal WAT were measured using in-house algorithms. Intrahepatic triglyceride (IHTG) was measured using MR spectroscopy and pancreatic fat was measured using a region-of-interest approach. Fat contents were compared between baseline and the first and second 6-month intervals using non-parametric analysis of Friedman's test and Wilcoxon's signed-rank test. Level of significance was selected at p=0.017 (0.05/3). Threshold of non-alcoholic fatty liver disease was set at 5.56%.ResultsResults indicated that BMI (p=0.005), IHTG (p=0.005), and subcutaneous (p=0.005) and visceral adipose tissues (p=0.005) were significantly reduced 6 months after surgery. Pancreatic fat (p=0.009) was significantly reduced at 12 months. Most reduction became stable between the 6-month and 12-month interval. No significant difference was observed in BAT volume, fat-fraction and T2* values.ConclusionThe results of this study suggest that bariatric surgery effectively reduced weight, mainly as a result of the reduction of abdominal WAT. Liver and pancreatic fat were deceased below the threshold possibly due to the reduction of free fatty acid. BAT volume, fat-fraction and T2* showed no significant changes, probably because surgery itself might not have altered the metabolic profile of the patients.Key Points center dot No significant changes were observed in fat-fraction, T2* and volume of brown adipose tissue after bariatric surgery.center dot Non-alcoholic fatty liver disease was resolved after surgery.center dot Abdominal white fat and liver fat were significantly reduced 6 months after surgery and become stable between 6 and 12 months while pancreatic fat was significantly reduced between 0 and 12 months.
出版社接受日期15.06.2018
著者Hui SCN, Wong SKH, Ai Q, Yeung DKW, Ng EKW, Chu WCW
期刊名稱European Radiology
出版年份2019
月份2
卷號29
期次2
出版社Springer
頁次849 - 856
國際標準期刊號0938-7994
電子國際標準期刊號1432-1084
語言美式英語
關鍵詞Magnetic resonance imaging, Magnetic resonance spectroscopy, Brown adipose tissue, White adipose tissue, Bariatric surgery

上次更新時間 2020-04-08 於 04:29