A Biotinylated and Endoplasmic Reticulum-Targeted Glutathione-Responsive Zinc(II) Phthalocyanine for Targeted Photodynamic Therapy
Publication in refereed journal

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其它資訊
摘要A biotinylated glutathione (GSH)‐responsive zinc(II) phthalocyanine has been prepared and characterized. With a 2,4‐dinitrobenzenesulfonyl moiety, its fluorescence emission and singlet oxygen generation were silenced in its intact state. Upon exposure to high concentration of GSH, its photosensitizing properties were restored in phosphate buffered saline and inside tumor cells. It also showed preferential uptake on HepG2 human hepatocarcinoma cells (with higher biotin receptor expression) rather than Chinese hamster ovary (CHO) cells (with lower biotin receptor expression). Upon irradiation, it caused photocytotoxicity with an IC50 value down to 0.1 μm on HepG2 cells. Moreover, it can localize in the endoplasmic reticulum (ER), causing ER stress after light irradiation.
出版社接受日期28.06.2018
著者Yu L, Wang Q, Yeung KW, Fong WP, Lo PC
期刊名稱Chemistry - An Asian Journal
詳細描述Special Issue: Chemical Tools and Materials for Biological/Medicinal Applications
出版年份2018
月份11
日期16
卷號13
期次22
出版社Wiley Online Library
頁次3509 - 3517
國際標準期刊號1861-4728
電子國際標準期刊號1861-471X
語言英式英語
關鍵詞GSH-responsive, activatable photosensitizers, biotin-targeting, photodynamic therapy, phthalocyanines

上次更新時間 2020-26-10 於 02:28