A Biotinylated and Endoplasmic Reticulum-Targeted Glutathione-Responsive Zinc(II) Phthalocyanine for Targeted Photodynamic Therapy
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AbstractA biotinylated glutathione (GSH)‐responsive zinc(II) phthalocyanine has been prepared and characterized. With a 2,4‐dinitrobenzenesulfonyl moiety, its fluorescence emission and singlet oxygen generation were silenced in its intact state. Upon exposure to high concentration of GSH, its photosensitizing properties were restored in phosphate buffered saline and inside tumor cells. It also showed preferential uptake on HepG2 human hepatocarcinoma cells (with higher biotin receptor expression) rather than Chinese hamster ovary (CHO) cells (with lower biotin receptor expression). Upon irradiation, it caused photocytotoxicity with an IC50 value down to 0.1 μm on HepG2 cells. Moreover, it can localize in the endoplasmic reticulum (ER), causing ER stress after light irradiation.
Acceptance Date28/06/2018
All Author(s) ListYu L, Wang Q, Yeung KW, Fong WP, Lo PC
Journal nameChemistry - An Asian Journal
Detailed descriptionSpecial Issue: Chemical Tools and Materials for Biological/Medicinal Applications
Volume Number13
Issue Number22
PublisherWiley Online Library
Pages3509 - 3517
LanguagesEnglish-United Kingdom
KeywordsGSH-responsive, activatable photosensitizers, biotin-targeting, photodynamic therapy, phthalocyanines

Last updated on 2021-04-05 at 00:26