Esophageal stress softening recovery is altered in the STZ-induced diabetic rats
Refereed conference paper presented and published in conference proceedings

香港中文大學研究人員
替代計量分析
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其它資訊
摘要This study investigated stress softening recovery in intact, separated muscle and mucosa-submucosa esophageal tubes in streptozotocin-induced diabetic rats. Fifteen Wistar rats were made diabetic (DM group) by intraperitoneal injection of 50 mg kg(-1) streptozotocin and another 11 rats served as Sham group by injection of saline. All rats survived for 8-weeks. Three series of inflation-deflation loadings at luminal pressure levels of 0.5, 1.0 and 2.0 kPa were carried out on different esophageal tubes. Five distension cycles on each pressure level were done in Ca++-free Krebs solution before and after KCl activation in Ca++-containing Krebs solution. The wall stiffness and stored energy recovery were compared between two groups. The stiffness was biggest in the DM group for the intact tube at pressure 0.5 kPa (P < 0.01) and for the muscle tube at all pressure levels (P < 0.05). Energy recovery induced by stress softening and stiffness loss recovery were significantly smaller in the DM group than in the Sham group for the intact esophagus and separated tubes at all pressure levels (P < 0.05, P < 0.01). In conclusion, the reversible stress softening and passive stiffness recovery were altered in STZ-induced diabetic rats. This study fills a gap in the knowledge about diabetes-induced esophageal remodeling.
著者Jiang H, Zhao J, Liao D, Wang G, Gregersen H
會議名稱FNM 2018 Congress
會議開始日29.08.2018
會議完結日01.09.2018
會議地點Amesterdam
會議國家/地區荷蘭
會議論文集題名JOURNAL OF BIOMECHANICS
出版作品名稱NEUROGASTROENTEROLOGY AND MOTILITY
出版年份2019
月份7
卷號92
出版社Elsevier
頁次126 - 136
國際標準期刊號0021-9290
電子國際標準期刊號1873-2380
語言英式英語
Web of Science 學科類別Gastroenterology & Hepatology;Clinical Neurology;Neurosciences;Gastroenterology & Hepatology;Neurosciences & Neurology

上次更新時間 2020-18-11 於 01:56