Predictors for delayed onset dementia after stroke or transient ischemic attack – a 5-year follow-up study
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AbstractIntroduction: We aimed to determine the association between baseline clinical and radiological factors and delayed onset dementia after stroke or transient ischemic attack (TIA).
Methods: We recruited consecutive subjects with stroke or TIA without early onset dementia. We conducted annual neuropsychological assessment for 5 years. We investigated the association between baseline demographic, clinical and radiological factors, as well as incident recurrent stroke with delayed onset dementia using Cox regression models.
Results: 1007 patients were recruited, of which 88 with early onset dementia and 162 who lost to all follow-up were excluded. 49 (6.5%) out of 757 patients have incident delayed onset dementia during the follow-up period. Using multi-variate cox regression, age (HR = 1.06, 95% CI 1.02 to 1.10,p=0.04), history of ischemic heart disease (HR = 2.64, 95% CI 1.23 to 5.66,p = 0.013), baseline waist circumference (HR = 1.03, 95% CI 1.00 to 1.06, p = 0.03) and the presence of ≥3 lacunes (HR = 3.04, 95% CI 1.60 to 5.77) were associated with delayed onset dementia after stroke. Rate of recurrent stroke was not different between patients with (4.1%) and without delay onset dementia (3.0%;p = 0.626)
Conclusion: Age, history of ischemic heart disease, baseline waist circumference and the presence of ≥3 lacunes are associated with delayed onset dementia after stroke/TIA
All Author(s) ListIsmail M, Lam BYK, Wong A, Abrigo JM, Chu WCW, Lau AYL, Soo YOY, Leung TWH, Mok VCT
Journal nameInternational Journal of Stroke
Year2018
Month10
Volume Number13
Issue NumberSuppl. 2
PublisherSAGE PUBLICATIONS LTD
Pages56 - 56
ISSN1747-4930
LanguagesEnglish-United States

Last updated on 2021-20-01 at 02:23