Predictors for delayed onset dementia after stroke or transient ischemic attack – a 5-year follow-up study
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AbstractIntroduction: We aimed to determine the association between baseline clinical and radiological factors and delayed onset dementia after stroke or transient ischemic attack (TIA).
Methods: We recruited consecutive subjects with stroke or TIA without early onset dementia. We conducted annual neuropsychological assessment for 5 years. We investigated the association between baseline demographic, clinical and radiological factors, as well as incident recurrent stroke with delayed onset dementia using Cox regression models.
Results: 1007 patients were recruited, of which 88 with early onset dementia and 162 who lost to all follow-up were excluded. 49 (6.5%) out of 757 patients have incident delayed onset dementia during the follow-up period. Using multi-variate cox regression, age (HR = 1.06, 95% CI 1.02 to 1.10,p=0.04), history of ischemic heart disease (HR = 2.64, 95% CI 1.23 to 5.66,p = 0.013), baseline waist circumference (HR = 1.03, 95% CI 1.00 to 1.06, p = 0.03) and the presence of ≥3 lacunes (HR = 3.04, 95% CI 1.60 to 5.77) were associated with delayed onset dementia after stroke. Rate of recurrent stroke was not different between patients with (4.1%) and without delay onset dementia (3.0%;p = 0.626)
Conclusion: Age, history of ischemic heart disease, baseline waist circumference and the presence of ≥3 lacunes are associated with delayed onset dementia after stroke/TIA
All Author(s) ListIsmail M, Lam BYK, Wong A, Abrigo JM, Chu WCW, Lau AYL, Soo YOY, Leung TWH, Mok VCT
Journal nameInternational Journal of Stroke
Volume Number13
Issue NumberSuppl. 2
Pages56 - 56
LanguagesEnglish-United States

Last updated on 2021-18-09 at 01:05