Air- and Light-Stable S-(Difluoromethyl)sulfonium Salts: C-Selective Electrophilic Difluoromethylation of beta-Ketoesters and Malonates
Publication in refereed journal

香港中文大學研究人員
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摘要Air- and light-stable electrophilic difluoromethylating reagents, S-(difluoromethyl)-S-phenyl-S-(2,4,6-trialkoxyphenyl) sulfonium salts were successfully developed, and the introduction of intramolecular hydrogen bonds plays a crucial role for the stabilities and reactivities of these reagents. C-selective difluoromethylation of a broad range of β-ketoesters and malonates proceeded smoothly under mild reaction conditions to give good to excellent yields with excellent C/O regioselectivities.
出版社接受日期25.09.2018
著者Sheng-Le Lu, Xin Li, Wen-Bing Qin, Jian-Jian Liu, Yi-Yong Huang, Henry N.C. Wong, Guo-Kai Liu
期刊名稱Organic Letters
出版年份2018
月份11
日期2
卷號20
期次21
出版社American Chemical Society
出版地Columbus, Ohio, USA
頁次6925 - 6929
國際標準期刊號1523-7060
電子國際標準期刊號1523-7052
語言美式英語
關鍵詞Difluoromethylation, sulfonium salts, malonate, ketoester

上次更新時間 2020-21-10 於 02:22