Air- and Light-Stable S-(Difluoromethyl)sulfonium Salts: C-Selective Electrophilic Difluoromethylation of beta-Ketoesters and Malonates
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AbstractAir- and light-stable electrophilic difluoromethylating reagents, S-(difluoromethyl)-S-phenyl-S-(2,4,6-trialkoxyphenyl) sulfonium salts were successfully developed, and the introduction of intramolecular hydrogen bonds plays a crucial role for the stabilities and reactivities of these reagents. C-selective difluoromethylation of a broad range of β-ketoesters and malonates proceeded smoothly under mild reaction conditions to give good to excellent yields with excellent C/O regioselectivities.
Acceptance Date25/09/2018
All Author(s) ListSheng-Le Lu, Xin Li, Wen-Bing Qin, Jian-Jian Liu, Yi-Yong Huang, Henry N.C. Wong, Guo-Kai Liu
Journal nameOrganic Letters
Volume Number20
Issue Number21
PublisherAmerican Chemical Society
Place of PublicationColumbus, Ohio, USA
Pages6925 - 6929
LanguagesEnglish-United States
KeywordsDifluoromethylation, sulfonium salts, malonate, ketoester

Last updated on 2021-17-09 at 23:53