Long non-coding RNAs in nucleus pulposus cell function and intervertebral disc degeneration
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AbstractIntervertebral disc degeneration (IDD) is the major cause of low back pain which incurs a significant public-health and economic burden. The aetiology of IDD is complex, with developmental, genetic, biomechanical and biochemical factors contributing to the disease development. Deregulated phenotypes of nucleus pulposus cells, including aberrant differentiation, apoptosis, proliferation and extracellular matrix deposition, are involved in the initiation and progression of IDD. Non-coding RNAs, including long non-coding RNAs (lncRNAs), have recently been identified as important regulators of gene expression. Research into their roles in IDD has been very active over the past 5 years. Our review summarizes current research regarding the roles of deregulated lncRNAs (eg, RP11-296A18.3, TUG1, HCG18) in modulating nucleus pulposus cell functions in IDD. These exciting findings suggest that specific modulation of lncRNAs or their downstream signalling pathways might be an attractive approach for developing novel therapeutics for IDD.
Acceptance Date01/05/2018
All Author(s) ListLi, Li, Chen, Li, Shen, Tse, Chan, Wu
Journal nameCell proliferation
Title of PublicationCell Proliferation
Detailed descriptionNational Natural Science Foundation of China (NSFC), Grant/Award Number: 81330044; The Capital Health Research and Development of Special, Grant/Award Number: 2016-1-409
Volume Number51
Issue Number5
LanguagesEnglish-United Kingdom

Last updated on 2021-07-03 at 01:16