Identification of genetic susceptibilities to low-dose mercury exposure in children
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摘要Background
Individual variability in the methylmercury(MeHg) metabolism and accumulation had been recognized for a long time. Genetic variations in glutathione (GSH)-related and metallothioneins (MTs) genes, which involved in producing enzymes in the MeHg metabolism pathway were proposed as one of the reasons for the differences in Hg metabolism from individual to individual.

Objectives
To investigate the impact of genetic variations in MTs and GSH-related genes on the association between fish consumption and body MeHg burden, as measured by hair Hg concentrations.

Methods
A total of 189 children and 165 mothers with either high or low fish consumption were recruited. Their hair total Hg (tHg) and MeHg levels and genotypes for GCLC, GCLM, GPx1, GSTA1, GSTP1, MT1A, MT2A, and MT4 were determined. Based on their 14-day food records, their amounts of fish consumed and their MeHg intakes were estimated. The impact of genetic variations on hair Hg concentrations was examined by using independent t tests and multivariate linear regressions.

Results
The mean hair MeHg and tHg levels were 0.58µg/g and 1.0µg/g for children, and 0.61µg/g and 1.03µg/g for mothers, respectively. The presence of variant alleles of GPx1, GCLC-129, GSTA1-52, GSTP1-105, and MT1M (rs2270836 and rs9936741) were associated with significant differences in hair Hg levels among children and mothers in the independent t tests. After adjustment for fish consumption and other confounding factors, mothers who carried a variant allele of GCLC-129, MT1M (rs9936741), and GPx1 have lower hair Hg levels whereas those with GSTP1-105 variant allele have higher hair Hg levels.

Conclusions
Our results showed that genetic variations in GSH-related and MTs gene have significant effects on body burden of Hg. These genetic variations might have a significant influence on MeHg metabolism and thus affecting the accumulation of Hg in our body. Understanding the genetic influence on body burden of Hg could facilitate the identification of people who are highly susceptible to MeHg exposure and improve the accuracy of current risk assessment.
出版社接受日期11.05.2018
著者Chan P.H.Y., Lam H.S., Chan K.Y.Y., Chau, S. C. L., Chan M.H.M., Cheung R., Li A.M.
會議名稱Health Research Symposium 2017
會議開始日16.06.2017
會議完結日16.06.2017
會議地點Hong Kong
會議國家/地區香港
出版年份2017
語言英式英語

上次更新時間 2018-29-10 於 17:26