Recent Advances in SELEX Technology and Aptamer Applications in Biomedicine
Publication in refereed journal

替代計量分析
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其它資訊
摘要Aptamers are short DNA/RNA oligonucleotides capable of binding to target molecules with high affinity and specificity. The process of selecting an aptamer is called Systematic Evolution of Ligands by Exponential Enrichment (SELEX). Thanks to the inherit merits, aptamers have been used in a wide range of applications, including disease diagnosis, targeted delivery agents and therapeutic uses. To date, great achievements regarding the selection, modifications and application of aptamers have been made. However, few aptamer-based products have already successfully entered into clinical and industrial use. Besides, it is still a challenge to obtain aptamers with high affinity in a more efficient way. Thus, it is important to comprehensively review the current shortage and achievement of aptamer-related technology. In this review, we first present the limitations and notable advances of aptamer selection. Then, we compare the different methods used in the kinetic characterization of aptamers. We also discuss the impetus and developments of the clinical application of aptamers.
出版社接受日期12.10.2017
著者Zhenjian Zhuo, Yuanyuan Yu, Maolin Wang, Jie Li, Zongkang Zhang, Jin Liu, Xiaohao Wu, Aiping Lu, Ge Zhang, Baoting Zhang
期刊名稱International Journal of Molecular Sciences
出版年份2017
月份10
日期14
卷號18
期次10
出版社MDPI
出版地Basel, Switzerland
文章號碼2142
國際標準期刊號1661-6596
語言英式英語
關鍵詞SELEX, aptamer, selection, targeted drug delivery systems, therapy

上次更新時間 2020-18-09 於 02:51