The 19q13 KRAB Zinc-finger protein ZFP82 suppresses the growth and invasion of esophageal carcinoma cells through inhibiting NF-κB transcription and inducing apoptosis
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AbstractAim: To study the epigenetic alternations and biological functions of ZFP82 in esophageal squamous cell carcinoma. Materials & methods: Analysis of ZFP82 expression was carried out by quantitative real-time PCR. Cell function was tested by MTS cell proliferation assay, transwell assay and flow cytometry. Gene mechanisms were studied by Reverse Transcription-Polymerase Chain Reaction (RT-PCR), quantitative real-time PCR, luciferase reporter assay and Western blot.Results:ZFP82 promoter methylation was downregulated in esophageal squamous cell carcinoma. ZFP82 ectopic expression suppressed cell function and regulated NF-κB phosphorylation and genes involved in cell cycle arrest and apoptosis. Moreover, ZFP82 methylation was correlated with age, tumor stage and outcome. Conclusion:ZFP82 is a tumor suppressor and is disrupted by promoter CpG methylation during esophageal carcinogenesis.
All Author(s) ListYe L, Xiang T, Fan Y, Zhang D, Li L, Zhang C, He X, Xiang Q, Tao Q, Ren G
Journal nameEpigenomics
Year2018
ISSN1750-1911
LanguagesEnglish-United States

Last updated on 2021-10-01 at 01:58