The impact of maternal gestational weight gain on cardiometabolic risk factors in children
Publication in refereed journal

替代計量分析
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其它資訊
摘要Aims/hypothesis
Accumulating evidence suggests an impact of gestational weight gain (GWG) on pregnancy outcomes; however, data on cardiometabolic risk factors later in life have not been comprehensively studied. This study aimed to evaluate the relationship between GWG and cardiometabolic risk in offspring aged 7 years.

Methods
We included a total of 905 mother–child pairs who enrolled in the follow-up visit of the multicentre Hyperglycemia and Adverse Pregnancy Outcome study, at the Hong Kong Centre. Women were classified as having gained weight below, within or exceeding the 2009 Institute of Medicine (IOM) guidelines. A standardised GWG according to pre-pregnancy BMI categories was calculated to explore for any quadratic relationship.

Results
Independent of pre-pregnancy BMI, gestational hyperglycaemia and other confounders, women who gained more weight than the IOM recommendations had offspring with a larger body size and increased odds of adiposity, hypertension and insulin resistance (range of p values of all the traits: 4.6 × 10−9 < p < 0.0390) than women who were within the recommended range of weight gain during pregnancy. Meanwhile, women who gained less weight than outlined in the recommendations had offspring with increased risks of hypertension and insulin resistance, compared with those who gained weight within the recommended range (7.9 × 10−3 < p < 0.0477). Quadratic relationships for diastolic blood pressure, AUC for insulin, pancreatic beta cell function and insulin sensitivity index were confirmed in the analysis of standardised GWG (1.4 × 10−3 < pquadratic < 0.0282). Further adjustment for current BMI noticeably attenuated the observed associations.

Conclusions/interpretation
Both excessive and inadequate GWG have independent and significant impacts on childhood adiposity, hypertension and insulin resistance. Our findings support the notion that adverse intrauterine exposures are associated with persistent cardiometabolic risk in the offspring.
出版社接受日期17.09.2018
著者Tam CHT, Ma RCW, Yuen LY, Ozaki R, Li AM, Hou Y, Chan MHM, Ho CS, Yang X, Chan JCN, Tam WH
期刊名稱Diabetologia
出版年份2018
月份12
卷號61
期次12
頁次2539 - 2548
國際標準期刊號0012-186X
語言英式英語
關鍵詞Adiposity, Cardiometabolic risk factors, Chinese children, Gestational weight gain, Hypertension Insulin resistance , Maternal pre-pregnancy, BMI

上次更新時間 2020-07-08 於 01:59