Critically discuss the revival of leptin for obesity therapy
Publication in refereed journal

香港中文大學研究人員
替代計量分析
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其它資訊
摘要Obesity has created a very serious public health problem, and World Health Organisation has actually warned that there is an urgent need for multinational cooperation to stem the rise of obesity. More than 20 years ago the discovery of Leptin, which is an adipocyte-secreted hormone and primarily acts on the hypothalamic neurons to activate the regulation of energy homeostasis, created much interest in its potential use for the treatment of obesity, but the hope was soon lost after leptin failed to counteract common diet-induced obesity. In recent years some preclinical studies have surprisingly demonstrated that resistance to leptin can be reversed and the effects of leptin therapy can be amplified by several leptin sensitisers. This paper will critically discuss the plausible revival of leptin for obesity therapy with reference to research findings on various influencing factors contributing to the level of expression and secretion of leptin.
著者Chi-Fai Lo
期刊名稱Psychology
出版年份2018
月份2
卷號9
期次2
出版社Scientific Research Publishing
文章號碼82444
頁次217 - 228
國際標準期刊號2152-7180
電子國際標準期刊號2152-7199
語言英式英語

上次更新時間 2020-08-08 於 01:33