Frequent Genetic Mismatch between Vaccine Strains and Circulating Seasonal Influenza Viruses, Hong Kong, China, 1996-2012
Publication in refereed journal

替代計量分析
.

其它資訊
摘要The World Health Organization selects influenza vaccine compositions biannually to cater to peaks in temperate regions. In tropical and subtropical regions, where influenza seasonality varies and epidemics can occur year-round, the choice of vaccine remains uncertain. Our 17-year molecular epidemiologic survey showed that most influenza A(H3N2) (9/11) and B (6/7) vaccine strains had circulated in East Asia >1 year before inclusion into vaccines. Northern Hemisphere vaccine strains and circulating strains in East Asia were closely matched in 7 (20.6%) of 34 seasons for H3N2 and 5 (14.7%) of 34 seasons for B. Southern Hemisphere vaccines also had a low probability of matching (H3N2, 14.7%; B, 11.1%). Strain drift among seasons was common (H3N2, 41.2%; B, 35.3%), and biannual vaccination strategy (Northern Hemisphere vaccines in November followed by Southern Hemisphere vaccines in May) did not improve matching. East Asia is an important contributor to influenza surveillance but often has mismatch between vaccine and contemporarily circulating strains.
著者Chan MCW, Wang MH, Chen ZG, Hui DSC, Kwok AK, Yeung ACM, Liu KM, Yeoh YK, Lee N, Chan PKS
期刊名稱Emerging Infectious Disease
出版年份2018
月份10
卷號24
期次10
出版社CENTERS DISEASE CONTROL
頁次1825 - 1834
國際標準期刊號1080-6040
電子國際標準期刊號1080-6059
語言英式英語
Web of Science 學科類別Immunology;Infectious Diseases;Immunology;Infectious Diseases

上次更新時間 2021-20-02 於 01:23