The use of 5% lidocaine medicated plaster for acute postoperative pain after gynecological surgery: A pilot randomized controlled feasibility trial
Publication in refereed journal


摘要Objectives: To examine the feasibility and potential efficacy of 5% lidocaine medicated plaster for acute postoperative pain in a parallel, blinded, randomized controlled pilot trial.

Methods: Twenty-eight women undergoing elective gynecological surgery with midline incisions were randomly allocated 5% lidocaine medicated patch (Lignopad) or placebo plasters. Postoperative pain at rest and on movement at 24hours were the primary study endpoints, with secondary endpoints of postoperative pain within the first 48hours, cumulative morphine consumption (mg), predicted peak flow rate (PFR) (%) and adverse effects. We assessed pain scores at rest and on movement using the visual analogue scale (0-100).

Results: The lidocaine patch group had lower postoperative pain scores at rest at 24hours (mean difference [MD] -15.1, 95% confidence interval [95% CI] -28.3 to -2.0; P=.024) but not on movement at 24hours (MD -6.4, 95% CI -22.7 to 9.9; P=.445). Compared to placebo, lidocaine may slightly lower cumulative morphine consumption (mg) over time (MD -3.4, 95% CI -6.9 to 0.2; group*time interaction P=.065). The difference in improvement in the PFR over time after surgery between groups appeared small (group*time P=.0980). No adverse effects occurred.

Conclusions: Lidocaine patch may provide a clinically important reduction in postoperative pain intensity. A larger trial to confirm the efficacy and safety of lidocaine patch is feasible after modifying the inclusion criteria and collecting patient-centered outcomes, such as quality of recovery and patient satisfaction.
著者Lau Lydia LN, Li Cheuk Yin, Lee Anna, Chan Simon KC
出版社Lippincott, Williams & Wilkins: Various Creative Commons / Wolters Kluwer
關鍵詞local anesthetics, pain management, transdermal patch

上次更新時間 2021-22-02 於 01:27