Real-time multi-channel SPR sensing based on DMD-enabled angular interrogation
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AbstractThis paper reports a digital micro-mirror device (DMD)-enabled real-time multi-channel biosensing system based on angular interrogation surface plasmon resonance (SPR). In the experiments, angular scanning is achieved by a DMD that facilitates SPR measurements using a single-point photodetector. In the four-channel measurement setup, real-time monitoring of bovine serum albumin (BSA) and anti-BSA binding interactions is performed at various concentration levels. The experimental results have verified that the system has a resolution of 3.54 × 10−6 RIU (refractive index unit); and a detection limit of 9 ng/mL. The new DMD-based SPR interrogation system presents a new design route for practical solid-state SPR biosensing with a user-selectable range of interrogation, enhanced signal-to-noise ratio, and fast data throughput.
Acceptance Date23/08/2018
All Author(s) ListDongping Wang, Fong-Chuen Loo, Hengji Cong, Wei Lin, Siu Kai Kong, Yeung Yam, Shih-Chi Chen, Ho Pui Ho
Journal nameOptics Express
Year2018
Month9
Day17
Volume Number26
Issue Number19
PublisherOSA
Place of PublicationUSA
Pages24627 - 24636
ISSN1094-4087
LanguagesEnglish-United States

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