Anti-inflammatory Activity of the Novel Cytokine Interleukin-38 in Allergic Asthma
Refereed conference paper presented and published in conference proceedings



摘要Interleukin (IL)-38 is a newly discovered cytokine which belongs to IL-1 cytokine family. It has been reported that IL-38 exerts anti-inflammatory activity in many diseases. The present study aimed to investigate the suppressive role of IL-38 in allergic asthmatic mice model. Ovalbumin (OVA)-induced mouse asthma model was established to evaluate the anti-inflammatory role of IL-38, and airway hyper-responsiveness was determined by Whole-body plethysmograph. The in vivo results showed that IL-38 injection could ameliorate airway obstruction in asthmatic mice through inhibiting the expression of T helper (Th)2-related cytokines IL-4, IL-5 and IL-13 in bronchalveolar lavage fluid (BALF) and lung homogenates as well as decreasing accumulation of eosinophils in BALF (all p<0.05). Histological examination indicated that IL-38 could alleviate lung inflammation in mice when compared with asthma group. Also, reduced Th2 and Th17 cells and increased Treg cells were observed in mice spleen after injection with IL-38 (all p<0.05). Taken together, our data confirmed the in vivo anti-inflammatory role of IL-38 in murine model of allergic asthma by attenuating Th2 and Th17 cells proliferation, and promoting Treg cells differentiation.
著者Xiaoyu Sun, Chun-Kwok Wong
會議名稱Annual Scientific Meeting, Hong Kong Society of Flow Cytometry
會議地點Hong Kong

上次更新時間 2018-06-12 於 10:52