The link between immunity, autoimmunity and endometriosis: a literature update
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AbstractEndometriosis (EMS), an estrogen-dependent inflammatory disorder affects approximately 5-10% of the general female population of reproductive age and 20-90% of women with pelvic pain and infertility. Many immunological factors are known to contribute significantly to the pathogenesis and pathophysiology of EMS, and both chronic local inflammation and autoantibodies in EMS shares many similarities with autoimmune diseases (AD). However, the autoimmune etiology in EMS remains controversial, and its evidence on autoimmune basis may be limited. Here we aim to review the current understanding between autoimmunity and EMS to provide important knowledge to develop future potential immunomodulatory therapy for the treatment of EMS.
Acceptance Date20/03/2018
All Author(s) ListZhang T, De Carolis C, Man GCW, Wang CC
Journal nameAutoimmunity Reviews
Year2018
Month10
Volume Number17
Issue Number10
PublisherELSEVIER SCIENCE BV
Pages945 - 955
ISSN1568-9972
LanguagesEnglish-United Kingdom
KeywordsEndometriosis (EMS), Autoimmune disease (AD), Autoantibodies, Complement (C), Cytokines, Immune escape, Immunomodulators

Last updated on 2020-19-09 at 04:14