Are skin equipment for assessing childhood eczema any good?
Publication in refereed journal


摘要Aim:Symptomatology and severity of atopic dermatitis (AD) can be objectively measured with equipment. This study aimed to compare skin measurements and investigate their correlations with various clinical severity scores.

Methods:Skin hydration (SH), transepidermal water loss (TEWL), pH, erythema, pigmentation and ITA (individual typology angle) were measured (using Delfin, Courage+Khazaka and Mettler Toledo equipment), and correlated with Patient-Oriented Eczema Measure (POEM, a short-term subjective-symptom score), Scoring Atopic Dermatitis
(SCORAD, a short-term subjective-symptom and objective-sign score), Nottingham Eczema Severity Score (NESS, a long-term subjective-symptom score), Children Dermatology Life Quality Index (CDLQI, a short-term subjective-symptom score) with Spearman's rho coefficient.

Results:80 sets of clinical scores from eczema patients (mean age: 10.8 ±4.9years; 44.6 % male) were evaluated. The POEM, objective SCORAD, CDLQI correlated well with each other. Skin pH ranged from 4.3-7.0 (mean 5.7±0.61). Skin pH, were correlated with Objective SCORAD components, including area (rho= 0.269, p=0.036), erythema (rho= 0.302, p=0.018) and lichenification (rho=0.365, p=0.026) and with the usage frequency of topical antibiotics. Skin pH was also correlated with other skin measurements, including SH (Delfin equipment: rho=-0.38, p<0.001). SH and TEWL as measured by Delfin equipment correlated better witha number of symptoms and signs than Courage+Khazaka equipmnt. Other clinical measurements including erythema, melanin, and skin colour did not demonstrate strong correlations with clinical symptom scores.

Conclusion:Skin pH (using Mettler Toledo), SH and TEWL (using Delfin equipment) correlated well with various clinical symptomatology scores. Less acidic pH appears to be associated with worse clinical scores of symptomatology, and increase usage of topical antibiotics, These findings not only support the supplementary usage of equipment in aiding objective documentation of clinical symptomatology in eczema therapeutic research but also
the advocacy of maintaining more acidic skin and avoiding alkaline soap and emollient products.
著者KL Hon, JSC Kung, WG Ng, KYC Tsang, NS Cheng, TF Leung
期刊名稱Journal of Dermatological Treatment
出版社Taylor & Francis
關鍵詞Atopic dermatitis, CDLQI, NESS, POEM, SCORAD, quality of life

上次更新時間 2021-20-01 於 02:19