The association of maternal gestational weight gain with children's insulin resistance and beta cell function – Follow‐up of the HAPO cohor
Refereed conference paper presented and published in conference proceedings


To determine the association of maternal gestational weight gain (GWG) with children's future cardiometabolic risk.
A total of 905 mothers who had joined the Hyperglycemia and Adverse Pregnancy Outcome study, were re‐evaluated together with their child born during the study period, at 7 years post‐delivery. Children's anthropometry, blood pressure (BP) were measured together with 5‐time point OGTT after receiving a glucose load of 1.75 g/kg body weight for measurements of plasma glucose and insulin. Obesity (BMI ≥95th percentile) and overweight (BMI ≥85th to <95th percentiles) were defined according the Centers for Disease Control and Prevention on the basis of age‐ and sex‐specific BMI percentiles for the local Chinese population. Maternal GWG were classified into 3 groups as below, within or above the recommendation of Institute of Medicine (IOM) for Weight Gain during Pregnancy.
By using regression model, children born to mothers whose GWG above recommendation had significantly higher rate of overweight/obesity (BMI ≥85th percentile) (21.8% versus 11.5%), higher diastolic BP (63 versus 61 mmHg), Insulinogenic index (60.5 versus 47.5), pancreatic beta cell functions (24.1 versus 21.1), HOMA beta cell function (57.1 versus 50.0) but lower Matsuda ISI (14.1 versus 15.5), than those born to mothers within IOM recommendation, after adjustment for maternal age, parity, pre‐pregnancy BMI, area under the curve of plasma glucose at OGTT, gestation age at delivery, mode of delivery, born large for gestation age, history of breastfeeding, children's sex, age and exercise level. We also found that maternal GWG had a positive linear association with children's adiposity and a U‐shaped association with diastolic BP, Matsuda ISI and Pancreatic Beta cell functions, independent of potential confounders. The enhanced beta cell functions of offspring born to mother with excessive GWG can be explained by a compensation for their insulin resistance.
Both inadequate and excessive maternal GWG in pregnancy was independently associated with children's higher cardiometabolic risk, namely hypertension and insulin resistance.
著者Tam WH, Tam HT, MA RCW, Yuen LY, NG ACW, Chan JCN
會議名稱The RCOG World Congress 2018
會議論文集題名BJOG - An International Journal of Obstetrics and Gynaecology
期次Supp 1
頁次112 - 112

上次更新時間 2020-30-07 於 01:12