Establishment of a Reference Database for Skin Physical Parameters in Chinese Children and Adolescents
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AbstractIntroduction: Atopic dermatitis (AD) is prevalent among children in Hong Kong. The disease is characterized by skin dryness, pruritus, and recurrent flexural dermatitis. The niche of the skin could be described by various physical parameters such as skin hydration (SH), transepidermal water loss (TEWL), redness (erythema) and pigmentation (melanin). Nowadays, biomedical devices for measuring these parameters have been developed, which can be integrated into routine primary care services and research. This study aims to build a dataset of these objective measurements to understand inter-individual variations among healthy children and adolescents in Hong Kong, and compare these measurements between AD patients and healthy controls.
Methods: Ethnic Chinese subjects aged below 20 years were recruited during the orientation day of our University and two health promotion events held in October 2016 and April 2017. SH, TEWL, erythema, and melanin were measured by Delfin MoistureMeterSC, Vapometer, and SkinColorCatch at the right mid-forearm respectively. These physical parameters were also measured in participants with self-reported eczema, and their AD severity was evaluated by Nottingham Eczema Severity Score (NESS). Participants with other active skin diseases were excluded. SH and TEWL were log-transformed before analyses. Independent T-test and Spearman’s correlation were used to analyse between-group differences and correlations respectively. All comparisons were made two-tailed, with p value < 0.05 being considered as statistically significant.
Results: A total of 245 subjects enrolled in this study. The mean (standard deviation [SD]) age of these healthy participants was 14.1 (4.6) years. Twenty-three percent of these subjects were male. Age was positively correlated with TEWL (ρ = 0.181, p = 0.016) and melanin (ρ = 0.253, p = 0.001). Male had significantly higher readings than female in terms of skin erythema (p < 0.001) and melanin (p = 0.010) measurements. Meanwhile, 69 subjects with AD were recruited during the two activities. The mean (SD) NESS was 5.8 (4.1). Age was positively correlated with TEWL (ρ = 0.237, p = 0.050). TEWL was significantly associated with AD after age adjustment (p < 0.001).
Conclusion: Skin integrity, redness and pigmentation are influenced by age and gender. TEWL may be a sensitive biomarker for AD in children and adolescents. This database of different cutaneous physical parameters serves as a reference for further research on different paediatric skin diseases in southern Chinese.
Acknowledgement: Funded by Research Committee’s One-off Fund for Research (3132910) of CUHK
All Author(s) ListYau Wing Ki Jennifer, Hon Kam Lun Ellis, Leung Ting Fan
Journal nameClinical and Translational Allergy
Volume Number8
Issue NumberSupplement 2
PublisherBMC (part of Springer Nature) / BioMed Central
Pages39 - 39
LanguagesEnglish-United Kingdom
KeywordsBiophysiology, eczema, skin hydration

Last updated on 2021-28-11 at 01:02