Adherent-invasive Escherichia coli in inflammatory bowel disease
Publication in refereed journal

香港中文大學研究人員
替代計量分析
.

其它資訊
摘要Intestinal microbiome dysbiosis has been consistently described in patients with IBD. In the last decades, Escherichia coli, and the adherent-invasive E coli (AIEC) pathotype in particular, has been implicated in the pathogenesis of IBD. Since the discovery of AIEC, two decades ago, progress has been made in unravelling these bacteria characteristics and its interaction with the gut immune system. The mechanisms of adhesion of AIEC to intestinal epithelial cells (via FimH and cell adhesion molecule 6) and its ability to escape autophagy when inside macrophages are reviewed here. We also explore the existing data on the prevalence of AIEC in patients with Crohn's disease and UC, and the association between the presence of AIEC and disease location, activity and postoperative recurrence. Finally, we highlight potential therapeutic strategies targeting AIEC colonisation of gut mucosa, including the use of phage therapy, bacteriocins and antiadhesive molecules. These strategies may open new avenues for the prevention and treatment of IBD in the future.
著者Palmela C, Chevarin C, Xu ZL, Torres J, Sevrin G, Hirten R, Barnich N, Ng SC, Colombel JF
期刊名稱Gut
出版年份2018
月份3
卷號67
期次3
出版社BMJ PUBLISHING GROUP
頁次574 - 587
國際標準期刊號0017-5749
電子國際標準期刊號1468-3288
語言英式英語
Web of Science 學科類別Gastroenterology & Hepatology;Gastroenterology & Hepatology

上次更新時間 2020-22-11 於 02:19