Adherent-invasive Escherichia coli in inflammatory bowel disease
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AbstractIntestinal microbiome dysbiosis has been consistently described in patients with IBD. In the last decades, Escherichia coli, and the adherent-invasive E coli (AIEC) pathotype in particular, has been implicated in the pathogenesis of IBD. Since the discovery of AIEC, two decades ago, progress has been made in unravelling these bacteria characteristics and its interaction with the gut immune system. The mechanisms of adhesion of AIEC to intestinal epithelial cells (via FimH and cell adhesion molecule 6) and its ability to escape autophagy when inside macrophages are reviewed here. We also explore the existing data on the prevalence of AIEC in patients with Crohn's disease and UC, and the association between the presence of AIEC and disease location, activity and postoperative recurrence. Finally, we highlight potential therapeutic strategies targeting AIEC colonisation of gut mucosa, including the use of phage therapy, bacteriocins and antiadhesive molecules. These strategies may open new avenues for the prevention and treatment of IBD in the future.
All Author(s) ListPalmela C, Chevarin C, Xu ZL, Torres J, Sevrin G, Hirten R, Barnich N, Ng SC, Colombel JF
Journal nameGut
Year2018
Month3
Volume Number67
Issue Number3
PublisherBMJ PUBLISHING GROUP
Pages574 - 587
ISSN0017-5749
eISSN1468-3288
LanguagesEnglish-United Kingdom
Web of Science Subject CategoriesGastroenterology & Hepatology;Gastroenterology & Hepatology

Last updated on 2020-04-04 at 11:55