Organophosphate and Pyrethroid Pesticide Exposures Measured before Conception and Associations with Time to Pregnancy in Chinese Couples Enrolled in the Shanghai Birth Cohort
Publication in refereed journal

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其它資訊
摘要BACKGROUND:
Pesticides have been associated with reproductive disorders, but there is limited research on pesticide exposures and human fertility.

OBJECTIVE:
We aimed to investigate the effects of preconception exposure to pesticides on time to pregnancy (TTP)and on infertility in a general population of couples planning to become pregnant in Shanghai, China.

METHODS:
A total of 615 women who were planning a pregnancy were enrolled before conception and were prospectively followed for 1y to observe their TTP. Preconception pesticide exposures were assessed by measuring urinary metabolites of organophosphates (OPs ) and pyrethroids (PYRs). Fecundability odds ratios (FORs) and odds ratios(ORs) of infertility were estimated using Cox and logistic regression models, respectively. All analyses were repeated after restricting the sample to nulliparous women (n=569).

RESULTS:
After adjusting for age, prepregnancy BMI, current smoking, education, annual household income, age at menarche, and two items from the Perceived Stress Scale (PSS-10), women in the highest quartile of diethylthiophosphate(DETP; an OP metabolite) had significantly longer TTP [adjusted FOR = 0:68 (95%CI:0.51,0.92)] and increased infertility [adjusted OR=2:17 (95%CI:1.19,3.93)] compared with women in the lowest quartile. The highest versus lowest quartile of 3-phenoxybenzoicacid (3PBA; a PYR metabolite) was associated with longer TTP and infertility, with
significant associations in nulliparous women [adjusted FOR=0:72 (95%CI:0.53,0.98); adjusted OR for infertility=2:03 (95%CI:1.10,3.74)].

CONCLUSION:
Our study provides some of the first evidence that preconception OP and PYR exposures are associated with decreased fertility in Chinese couples. Given that OPs and PYRs are rapidly metabolized in humans, more studies are needed to confirm our findings.
出版社接受日期10.05.2018
著者Hu Y, Ji L, Zhang Y, Shi R, Han WC, Tse LA, Pan R, Wang YW, Ding GD, Xu J, Zhang QY, Gao Y, Tian Y
期刊名稱Environmental Health Perspectives
出版年份2018
月份7
卷號126
期次7
文章號碼077001
國際標準期刊號0091-6765
電子國際標準期刊號1552-9924
語言英式英語

上次更新時間 2021-22-02 於 01:15