High serum folate is associated with brain atrophy in older diabetic people with vitamin B12 deficiency
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摘要Previous studies have reported the adverse cognitive effects of high folate status in older individuals with vitamin B12 (VB12) deficiency. Thus, the aim of this study was to investigate how high serum folate and VB12 deficiency could collaboratively aggravate neuronal degeneration. In total, 146 older non-demented diabetic individuals with an average age of 75 +/- 3.9 were recruited. VB12 deficiency and high folate status were based on high serum methylmalonic acid (MMA) concentrations (> 0.3 mu mol/L) and the serum folate concentration being in the top tertile (> 31.4 nmol/L) respectively. Among these subjects, there were 20 with elevated MMA and high folate. The structural magnetic resonance imaging data of these subjects were analyzed by performing flexible factorial analysis with the "folate level" and "MMA level" added as main effects, and the interaction effect of folate and VB12 on brain volume was evaluated. The results showed significant gray matter atrophy of the right middle occipital gyrus and the opercular part of the inferior frontal gyrus in subjects with a simultaneous high folate status and VB12 deficiency. Together with previous observational studies on cognitive function, this study lends support to the notion that high serum folate concentrations in older people with VB12 deficiency may be associated with increased neurodegeneration..
著者Deng Y, Wang D, Wang K, Kwok T
期刊名稱Journal of Nutrition, Health and Aging
出版年份2017
月份11
卷號21
期次9
出版社Springer
頁次1065 - 1071
國際標準期刊號1279-7707
電子國際標準期刊號1760-4788
語言英式英語
關鍵詞Vitamin B12, folate, methylmalonic acid, magnetic resonance imaging, older people
Web of Science 學科類別Geriatrics & Gerontology;Nutrition & Dietetics;Geriatrics & Gerontology;Nutrition & Dietetics

上次更新時間 2020-19-10 於 03:48