Structural and microstructural intra-articular bone changes at the metacarpal heads in patients with psoriatic arthritis compared to controls: a HR-pQCT study
Refereed conference paper presented and published in conference proceedings


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摘要Background: Located inside the joint capsule,1 the entire metacarpal head (MCH) is directly exposed to intra-articular inflammatory milieu in patients with psoriatic arthritis (PsA). We hypothesise that bone loss and new bone formation in the MCH will be more prominent in PsA compared to healthy controls.

Objectives: To investigate structural (bone erosion and enthesiophyte) and microstructural intra-articular bone changes in patients with PsA at the second and third MCH (MCH 2 and 3) compared with controls.

Methods: 139 subjects (77PsA, 62 control) underwent HR CT scanning at the MCH 2 and 3 and distal radius. 15 patients with joint destruction2 were excluded from further analysis. An integrative CART-EBEE approach was developed to investigate the structural and microstructural bone changes. CART method (AB) was used to calculate volume of bone erosion and enthesiophyte [Crop of metacarpal bone(a,b); Automated segmentation of periosteal surface (c,e);Restoration of the missing cortical boundary based on anatomic curve(d,f);Three-dimensional calculation of volume(g)]; EBEE method was used to calculate volumetric bone mineral density (vBMD) and microstructure before and after exclusion of Bone Erosion (C) and Enthesiophyte (D).

Results: 62 patients with PsA and controls were comparable in age, gender and body mass index. PsA patients had a significantly increased number (mean ±SD/patient 2.4±1.4 vs 1.3±1.1, p<0.001) and total volume of enthesiophytes (8.75±6.92 vs 4.36±4.90 mm3, p<0.001); but a similar number of bone erosion (mean ±SD/patient 2.9±1.2 vs 2.7±1.4, p=0.408) and a trend suggestive of an increase in total volume of bone erosion (11.88±7.82 vs 9.64±5.96 mm3, p=0.076) per person compared with control. Depth of each individual bone erosion was greater in PsA than control; while no differences in the maximal height of each individual enthesiophyte was found between PsA and control. With regards to the microstructure, PsA showed a significantly decreased total vBMD, cortical vBMD (Ct.vBMD) and Ct. thickness at the distal radius; while a preferential bone loss at the trabecular (Tb.) compartment [Tb. vBMD; trabecular bone volume fraction [BV/TV] and Tb. thickness] was observed at the MCH compared to control. After excluding of enthesiophyte, a further deterioration in the Ct. compartment (vBMD, perimeter, thickness) in PsA patients was observed. Regression model in PsA and controls indicated that PsA was independently associated with an increased total volume of enthesiophytes per person. Regression model in PsA showed that CRP, older age and higher BMI were independently associated with an increase in the total volume of bone erosion. On the other hand, older age was independently associated with an increase in total volume of enthesiohyte per person.
著者Dongze Wu, James F Griffith, Steven H.M. Lam, Priscilla Wong, Jiang Yue, Lin Shi, Edmund K. Li, Isaac T. Cheng, Tena K. Li, Tracy Y. Zhu, Vivian W. Hung, Ling Qin, Lai-Shan Tam
會議名稱Congress of the European-League-Against-Rheumatism (EULAR)
會議開始日13.06.2018
會議完結日16.06.2018
會議地點Amsterdam
會議國家/地區荷蘭
會議論文集題名Annals of the Rheumatic Diseases
出版年份2018
月份6
卷號77
期次Suppl 2
出版社BMJ
國際標準期刊號0003-4967
電子國際標準期刊號1468-2060
語言美式英語

上次更新時間 2020-13-10 於 03:18